Locksmith

Loading game…

Matchup summary

The White Sox take on the Guardians in MLB action on Wednesday, September 16 at 1:11 PM ET. White Sox are getting +148 on the moneyline with the total at 7.5. Market win probability leans Guardians at 62.5%. Odds from 7 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: White Sox betting trends · Guardians betting trends · all MLB games

White Sox vs Guardians Prediction, Odds & Picks — Sep 16, 2026 | Locksmith