Locksmith

Loading game…

Matchup summary

The Guardians take on the Red Sox in MLB action on Tuesday, September 22 at 6:46 PM ET. Guardians are getting +106 on the moneyline with the total at 6.5. Market win probability leans Red Sox at 54%. Odds from 6 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Guardians betting trends · Red Sox betting trends · all MLB games

Guardians vs Red Sox Prediction, Odds & Picks — Sep 22, 2026 | Locksmith