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Matchup summary

The Astros take on the Mariners in MLB action on Tuesday, September 22 at 9:41 PM ET. Astros are getting +122 on the moneyline with the total at 7.5. Market win probability leans Mariners at 56.1%. Odds from 4 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Astros betting trends · Mariners betting trends · all MLB games

Astros vs Mariners Prediction, Odds & Picks — Sep 22, 2026 | Locksmith