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Matchup summary

The Cardinals take on the Pirates in MLB action on Tuesday, September 22 at 6:41 PM ET. Cardinals are getting +124 on the moneyline with the total at 7.5. Market win probability leans Pirates at 57.5%. Odds from 6 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Cardinals betting trends · Pirates betting trends · all MLB games

Cardinals vs Pirates Prediction, Odds & Picks — Sep 22, 2026 | Locksmith