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Matchup summary

The White Sox take on the Guardians in MLB action on Monday, September 14 at 6:40 PM ET. Line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: White Sox betting trends · Guardians betting trends · all MLB games

White Sox vs Guardians Prediction, Odds & Picks — Sep 14, 2026 | Locksmith