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Matchup summary

The Villanova take on the #24 Louisville in College Football action on Friday, September 11 at 7:00 PM ET. Villanova are getting +2585 on the moneyline with the total at 56.5. Market win probability leans Louisville at 97.5%. Odds from 6 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Villanova betting trends · Louisville betting trends · all College Football games

Villanova vs #24 Louisville Prediction, Odds & Picks — Sep 11, 2026 | Locksmith