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Matchup summary

The Iowa State take on the #22 Iowa in College Football action on Saturday, September 12 at 7:30 PM ET. Iowa State are getting +490 on the moneyline with the total at 41.5. Market win probability leans Iowa at 84.5%. Odds from 8 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Iowa State betting trends · Iowa betting trends · all College Football games

Iowa State vs #22 Iowa Prediction, Odds & Picks — Sep 12, 2026 | Locksmith