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Matchup summary

The Louisiana take on the #14 USC in College Football action on Saturday, September 12 at 11:00 PM ET. Louisiana are getting +2500 on the moneyline with the total at 60.5. Market win probability leans USC at 96.3%. Odds from 9 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Louisiana betting trends · USC betting trends · all College Football games

Louisiana vs #14 USC Prediction, Odds & Picks — Sep 12, 2026 | Locksmith