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Matchup summary

The Buffalo take on the #18 Penn State in College Football action on Saturday, September 19 at 12:00 PM ET. Market win probability leans Penn State at 97.5%. Line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Buffalo betting trends · Penn State betting trends · all College Football games

Buffalo vs #18 Penn State Prediction, Odds & Picks — Sep 19, 2026 | Locksmith