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Matchup summary

The #19 SMU take on the #24 Louisville in College Football action on Saturday, September 19 at 3:30 PM ET. The consensus line has SMU favored at -105 on the moneyline with the total sitting at 56.5. Market win probability leans SMU at 51.7%. Line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: SMU betting trends · Louisville betting trends · all College Football games

#19 SMU vs #24 Louisville Prediction, Odds & Picks — Sep 19, 2026 | Locksmith