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Matchup summary

The #21 Oregon take on the #12 USC in College Football action on Saturday, September 26 at 7:30 PM ET. The consensus line has Oregon favored at -100 on the moneyline with the total sitting at 61.5. Market win probability leans Oregon at 50.2%. Odds from 4 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Oregon betting trends · USC betting trends · all College Football games

#21 Oregon vs #12 USC Prediction, Odds & Picks — Sep 26, 2026 | Locksmith