Matchup summary

The 49ers take on the Rams in NFL action on Thursday, September 10 at 8:35 PM ET. 49ers are getting +162 on the moneyline with the total at 48.5. Market win probability leans Rams at 63.5%. Odds from 7 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: 49ers betting trends · Rams betting trends · all NFL games