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Matchup summary

The Dolphins take on the 49ers in NFL action on Sunday, September 20 at 4:25 PM ET. Dolphins are getting +495 on the moneyline with the total at 46.5. Market win probability leans 49ers at 84.1%. Odds from 3 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Dolphins betting trends · 49ers betting trends · all NFL games

Dolphins vs 49ers Prediction, Odds & Picks — Sep 20, 2026 | Locksmith