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Matchup summary

The Colts take on the Chiefs in NFL action on Sunday, September 20 at 8:20 PM ET. Colts are getting +262 on the moneyline with the total at 47.5. Market win probability leans Chiefs at 73.5%. Odds from 3 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Colts betting trends · Chiefs betting trends · all NFL games

Colts vs Chiefs Prediction, Odds & Picks — Sep 20, 2026 | Locksmith