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Matchup summary

The Texans take on the Colts in NFL action on Sunday, September 27 at 1:00 PM ET. The consensus line has Texans favored at -140 on the moneyline with the total sitting at 45.5. Market win probability leans Texans at 56.8%. Odds from 7 books, line movement, sharp money splits, and every graded Locksmith pick on this matchup update on this page through game time.

More on this matchup: Texans betting trends · Colts betting trends · all NFL games

Texans vs Colts Prediction, Odds & Picks — Sep 27, 2026 | Locksmith